augustus ☆
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Description:
Predict genes in eukaryotic genomic sequences
Type: Formula  |  Latest Version: 3.5.0@12  |  Tracked Since: Dec 17, 2025
Links: Homepage  |  formulae.brew.sh
Category: Other
Tags: bioinformatics genomics gene-prediction eukaryotic ab-initio
Install: brew install augustus
About:
AUGUSTUS is a gene prediction program for eukaryotic genomic sequences. It can be used as an ab initio program, meaning it predicts genes based solely on the genomic sequence. It also supports hints from other sources like EST alignments or protein homology to improve prediction accuracy.
Key Features:
  • Ab initio gene prediction using statistical models
  • Integration of external hints (ESTs, RNA-seq, protein homology)
  • Support for alternative splicing and UTR prediction
  • Species-specific training parameters available
Use Cases:
  • Annotating newly sequenced eukaryotic genomes
  • Improving gene models using RNA-seq or EST evidence
  • Comparative genomics studies
Alternatives:
  • GeneMark – GeneMark is another popular gene finder, often noted for its self-training capabilities on prokaryotic and eukaryotic sequences.
  • Glimmer – Glimmer is primarily used for prokaryotic and microbial eukaryotic gene finding, focusing on interpolated Markov models.
License: Artistic-1.0
Dependencies: bamtools, boost, htslib
Bottles available for: arm64_tahoe, arm64_sequoia, arm64_sonoma, sonoma, arm64_linux, x86_64_linux
Version History
Detected Version Rev Change Commit
Sep 13, 2025 12:44pm 11 VERSION_BUMP 35f19d52
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