bcftools ☆
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Description:
Tools for BCF/VCF files and variant calling from samtools
Type: Formula  |  Latest Version: 1.23@0  |  Tracked Since: Dec 17, 2025
Links: Homepage  |  formulae.brew.sh
Category: Developer tools
Tags: bioinformatics genomics variant-calling htslib data-analysis
Install: brew install bcftools
About:
BCFtools is a comprehensive set of utilities for variant calling and manipulating files in the BCF/VCF format. It provides a robust suite of commands for filtering, summarizing, and collating genomic variants. As a core component of the samtools ecosystem, it is essential for processing high-throughput sequencing data.
Key Features:
  • Indexing and querying of variant files
  • Filtering and quality control of variants
  • Variant manipulation and format conversion
  • Consensus sequence creation
Use Cases:
  • Filtering variants from a genome-wide association study (GWAS)
  • Merging variant calls from multiple samples
  • Converting between VCF and BCF formats for efficient processing
Alternatives:
  • VCFtools – VCFtools is another popular suite but is often considered deprecated in favor of BCFtools for newer analyses.
License: GPL-3.0-or-later
Dependencies: gsl, htslib
Bottles available for: arm64_tahoe, arm64_sequoia, arm64_sonoma, sonoma, arm64_linux, x86_64_linux
Version History
Detected Version Rev Change Commit
Dec 16, 2025 4:57pm 0 VERSION_BUMP 41e057da
Sep 13, 2025 12:38pm 0 VERSION_BUMP 29b2ff1a
Sep 12, 2024 10:11pm 0 VERSION_BUMP 202d0a74
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