Description:
Accelerated BLAST compatible local sequence aligner
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Type: Formula
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Latest Version: 2.1.16@0
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Tracked Since: Dec 17, 2025
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Links:
Homepage |
formulae.brew.sh
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Category: Other
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Tags:
bioinformatics
sequence-alignment
blast
genomics
cli
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Install:
brew install diamond
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About:
DIAMOND is a sequence aligner for protein and translated DNA searches, designed for high performance against large protein reference databases. It achieves alignment speeds up to 20,000 times faster than BLASTX while maintaining high sensitivity. This allows researchers to process massive Next-Generation Sequencing datasets on standard desktop computers.
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Key Features:
- Ultra-fast alignment speed (up to 20,000x faster than BLASTX)
- BLAST-compatible output formats (tabular, XML, SAM)
- Low memory footprint for large reference databases
- Supports sensitive and fast modes for different search requirements
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Use Cases:
- Metagenomic classification of sequencing reads against large protein databases
- Large-scale homology searches for gene annotation
- Processing NGS data on standard workstations without HPC access
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Alternatives:
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BLAST+
– Standard tool with higher sensitivity but significantly slower performance
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HMMER
– Better for detecting remote homologs using profile hidden Markov models
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