diamond ☆
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Description:
Accelerated BLAST compatible local sequence aligner
Type: Formula  |  Latest Version: 2.1.16@0  |  Tracked Since: Dec 17, 2025
Links: Homepage  |  formulae.brew.sh
Category: Other
Tags: bioinformatics sequence-alignment blast genomics cli
Install: brew install diamond
About:
DIAMOND is a sequence aligner for protein and translated DNA searches, designed for high performance against large protein reference databases. It achieves alignment speeds up to 20,000 times faster than BLASTX while maintaining high sensitivity. This allows researchers to process massive Next-Generation Sequencing datasets on standard desktop computers.
Key Features:
  • Ultra-fast alignment speed (up to 20,000x faster than BLASTX)
  • BLAST-compatible output formats (tabular, XML, SAM)
  • Low memory footprint for large reference databases
  • Supports sensitive and fast modes for different search requirements
Use Cases:
  • Metagenomic classification of sequencing reads against large protein databases
  • Large-scale homology searches for gene annotation
  • Processing NGS data on standard workstations without HPC access
Alternatives:
  • BLAST+ – Standard tool with higher sensitivity but significantly slower performance
  • HMMER – Better for detecting remote homologs using profile hidden Markov models
Version History
Detected Version Rev Change Commit
Nov 10, 2025 7:54pm 0 VERSION_BUMP 530bd9e2
Sep 15, 2025 2:26am 0 VERSION_BUMP a98bb24d
Sep 14, 2025 1:50pm 0 VERSION_BUMP bbe6b8f6
Sep 12, 2025 2:15pm 0 VERSION_BUMP 9b753dcc
Sep 11, 2025 10:11am 0 VERSION_BUMP d2b4eb92
Dec 21, 2024 1:40am 0 VERSION_BUMP a5e072e3
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