fgbio ☆

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Description:
Tools for working with genomic and high throughput sequencing data

Type: Formula | Tracked Since: Dec 28, 2025

Links: Homepage | formulae.brew.sh

Category: Other

Tags: genomics bioinformatics sequencing umi cli

Install: brew install fgbio

About:
Fgbio is a command-line toolkit for processing and analyzing high-throughput sequencing data. It provides robust tools for handling unique molecular identifiers (UMIs), performing consensus calling, and executing common bioinformatics tasks. The suite focuses on accuracy and efficiency for genomic data workflows.

Key Features:

UMI-aware read processing and consensus calling
Tools for manipulating SAM/BAM/CRAM files
Utilities for variant calling and filtering
Supports common sequencing data formats

Use Cases:

Processing amplicon sequencing data with UMIs
Creating duplex consensus reads to reduce errors
Converting and filtering genomic alignment files

Alternatives:

Picard – Picard is a Java-based suite for manipulating high-throughput sequencing data, often used for similar file manipulation tasks but Fgbio specializes in UMI workflows.
Samtools – Samtools is a lower-level utility for manipulating alignments in SAM/BAM format, whereas Fgbio provides higher-level analysis tools specifically for UMI data.

Version History

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