freebayes ☆
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Description:
Bayesian haplotype-based genetic polymorphism discovery and genotyping
Type: Formula  |  Tracked Since: Dec 28, 2025
Links: Homepage  |  formulae.brew.sh
Category: Other
Tags: bioinformatics genomics variant-calling bayesian dna-sequencing
Install: brew install freebayes
About:
FreeBayes is a Bayesian genetic variant caller designed for finding SNPs, indels, and complex variants from high-throughput sequencing data. It leverages haplotype-based analysis to improve accuracy in regions of high polymorphism and reduces false positives by considering multiple samples simultaneously.
Key Features:
  • Bayesian inference for variant calling
  • Haplotype-based detection
  • Multi-sample calling capabilities
  • Detection of SNPs, indels, and MNPs
Use Cases:
  • Population genetics studies
  • Cancer genomics analysis
  • Rare variant discovery
Alternatives:
  • GATK HaplotypeCaller – Java-based alternative with similar haplotype approach but heavier resource requirements
  • BCFtools – Lightweight variant manipulation toolkit, less sophisticated calling algorithm
Version History
Detected Version Rev Change Commit
Nov 3, 2024 9:07pm 0 VERSION_BUMP da505166
Dec 3, 2023 11:23am 0 VERSION_BUMP 35ec7f28
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