mafft ☆
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Description:
Multiple alignments with fast Fourier transforms
Type: Formula  |  Tracked Since: Dec 28, 2025
Links: Homepage  |  formulae.brew.sh
Category: Other
Tags: bioinformatics sequence-alignment genomics scientific-computing cli
Install: brew install mafft
About:
MAFFT is a sophisticated multiple sequence alignment program designed for high throughput and accuracy. It utilizes fast Fourier transforms to rapidly identify homologous regions, making it exceptionally efficient for aligning large datasets. The tool offers several distinct algorithms to balance speed and precision according to user requirements.
Key Features:
  • High-speed alignment using Fast Fourier Transform
  • Multiple algorithm strategies (e.g., FFT-NS-2, L-INS-i)
  • Scalable for large datasets and genomic sequences
  • Supports nucleotide and amino acid sequences
Use Cases:
  • Phylogenetic analysis preparation
  • Identifying conserved domains in protein families
  • Comparative genomics research
Alternatives:
  • Clustal Omega – Widely used but generally slower than MAFFT on large datasets
  • MUSCLE – Another fast algorithm, often comparable to MAFFT in speed and accuracy
Version History
Detected Version Rev Change Commit
Sep 16, 2025 2:55am 0 VERSION_BUMP d0689c8b
Sep 13, 2024 7:50pm 0 VERSION_BUMP 9555957e
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