trimal
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Description:
Automated alignment trimming in large-scale phylogenetic analyses
Type: Formula  |  Tracked Since: Dec 28, 2025
Links: Homepage  |  formulae.brew.sh
Category: Other
Tags: bioinformatics phylogenetics alignment genomics scientific-computing
Install: brew install trimal
About:
Trimal is a tool for the automated trimming of DNA and protein alignments. It uses multiple metrics to identify and remove poorly aligned regions, which can significantly improve the accuracy of phylogenetic trees. This is essential for handling the noise and gaps often found in large-scale sequence datasets.
Key Features:
  • Automated detection of problematic alignment regions
  • Supports multiple trimming algorithms (e.g., gappy, strict)
  • Generates reports for visual inspection of alignment quality
  • Outputs trimmed alignments in standard formats (e.g., FASTA, PHYLIP)
Use Cases:
  • Preparing alignments for phylogenetic inference (e.g., RAxML, MrBayes)
  • Improving the accuracy of phylogenomic analyses by removing noisy data
  • Standardizing alignment quality across large datasets
Alternatives:
  • Gblocks – An older, widely used tool for the same purpose, but Trimal offers more algorithms and automation.
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