minigraph ☆

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Description:
Proof-of-concept seq-to-graph mapper and graph generator

Type: Formula | Tracked Since: Dec 28, 2025

Links: Homepage | formulae.brew.sh

Category: Other

Tags: bioinformatics genomics sequence-alignment pangenome graph-analysis

Install: brew install minigraph

About:
Minigraph is a specialized tool for constructing pan-genome graphs from reference sequences and mapping long sequencing reads to these graphs. It uniquely combines graph construction and read mapping into a single efficient pipeline, enabling rapid analysis of genetic variation beyond linear references.

Key Features:

Ultra-fast graph construction and read mapping
Supports variant-aware pangenome graph structures
Optimized for noisy long-read sequencing data
Memory-efficient algorithm design

Use Cases:

Building pan-genome graphs from assembled genomes
Mapping long-read sequences to complex genomic regions
Analyzing structural variants across multiple samples

Alternatives:

minimap2 – More general-purpose mapper; minigraph is specialized for graph-based alignment
vg – More complex graph operations; minigraph focuses on speed and simplicity

Version History

Detected	Version	Rev	Change	Commit
Sep 15, 2025 10:38pm		0	VERSION_BUMP	f071a63f
Sep 14, 2024 4:08am		0	VERSION_BUMP	07da4a6e