minimap2 ☆
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Description:
Versatile pairwise aligner for genomic and spliced nucleotide sequences
Type: Formula  |  Tracked Since: Dec 28, 2025
Links: Homepage  |  formulae.brew.sh
Category: Other
Tags: bioinformatics alignment genomics sequencing cli
Install: brew install minimap2
About:
Minimap2 is a versatile sequence aligner designed for mapping long reads or contigs to large reference genomes. It excels in both genomic and spliced nucleotide alignments, offering a fast and memory-efficient solution for modern sequencing data analysis.
Key Features:
  • Fast and memory-efficient alignment
  • Supports long reads (ONT, PacBio) and short reads
  • Handles spliced alignment for transcript mapping
  • Includes features like SV calling and paf summarization
Use Cases:
  • Mapping long-read sequencing data to a reference genome
  • Aligning assembly contigs to a reference
  • Identifying structural variants from aligned reads
  • Mapping cDNA sequences to a genome
Alternatives:
  • BWA-MEM – BWA-MEM is highly accurate for short reads but less efficient for long reads compared to Minimap2.
  • BLAST – BLAST is a general-purpose alignment tool for homology search, whereas Minimap2 is optimized for genomic mapping and long reads.
Version History
Detected Version Rev Change Commit
Sep 15, 2025 10:41pm 0 VERSION_BUMP 8bf2d3bb
Sep 14, 2024 4:07am 0 VERSION_BUMP 08ce0f55
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