rna-star ☆
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Description:
RNA-seq aligner
Type: Formula  |  Latest Version: 2.7.11b@0  |  Tracked Since: Dec 28, 2025
Links: Homepage  |  formulae.brew.sh
Category: Other
Tags: bioinformatics genomics rna-seq alignment sequencing
Install: brew install rna-star
About:
STAR (Spliced Transcripts Alignment to a Reference) is an ultrafast RNA-seq aligner designed for aligning RNA-seq reads to a reference genome. It utilizes a two-step process involving genome indexing and subsequent read mapping, efficiently handling spliced alignments and detecting chimeric and circular transcripts. Its speed and accuracy make it a standard tool in modern transcriptomics pipelines.
Key Features:
  • Ultrafast alignment of RNA-seq reads
  • Accurate detection of splice junctions and chimeric transcripts
  • Supports full-length RNA-seq read alignment
  • Includes tools for quantification (STAR-Fusion, counts)
Use Cases:
  • Aligning RNA-seq data for differential gene expression analysis
  • Identifying novel splice junctions and structural variations
  • Detecting gene fusions in cancer research
Alternatives:
  • HISAT2 – HISAT2 is generally slower but uses less memory than STAR.
  • Bowtie2 – Bowtie2 is primarily designed for DNA alignment and does not inherently handle splicing.
Version History
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